Our laboratory has focused for the past two decades on a large family of cell-surface receptors called Frizzled. This name refers to the appearance of fruit flies in which the receptor gene is mutated: the hairs and bristles on the body surface of Frizzled mutant flies are oriented inappropriately.
Wang, Y., Smallwood, P.M., Williams, J., and Nathans, J. (2020) A mouse model for Kinesin Family Member 11 (Kif11) associated familial exudative vitreoretinopathy. Human Molecular Genetics 29: 1121-1131.
Chang, T.-H., Hsieh, F.-L., Smallwood, P.M., Gabelli, S.B., and Nathans, J. (2020) Structure of the RECK CC domain, an evolutionary anomaly. Proceedings of the National Academy of Sciences USA 117: 15104-15111.
Rattner, A., Terrillion, C.E., Jou, C., Kleven, T., Hu, S.F., Williams, J., Hou, Z., Aggarwal, M., Mori, S., Shin, G., Goff, L.A., Witter, M.P., Pletnikov, M., Fenton, A.A., and Nathans, J. (2020) Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. eLife 9: e62766.
Wang, J., Rattner, A., and Nathans, J. (2021) A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation. eLife. 10: e73477.
Wang, Y., Venkatesh, A., Xu, J., Xu, M., Williams, J., Smallwood, P.M., and Nathans, J. (2022) The WNT7A/WNT7B/GPR124/RECK Signaling Module Plays an Essential Role in Mammalian Limb Development. Development 149: dev200340.