Selected Recent Publications (for a complete listing enter “Nathans J” in PubMed)

Wang Y., Zhang J., Mori S., and Nathans J. (2006) Axonal growth and guidance defects in Frizzled3 knockout mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling. Journal of Neuroscience 26: 355-364. PMID: 16407530

Wang Y., Guo N., and Nathans J. (2006) The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner ear sensory hair cells. Journal of Neuroscience 26: 2147-2156.PMID: 16495441

Wang, Y. Badea, T., and Nathans, J. (2006) Order from disorder: self-organization in mammalian hair patterning. Proceedings of the National Academy of Sciences USA 103: 19800-19805. PMID: 17172440

Wang, Y., and Nathans, J. (2007) Tissue/planar cell polarity in vertebrates: new insights and new questions. Development 134: 647-658. PMID: 17259302

Jacobs, G.H., Williams, G.A., Cahill, H., and Nathans, J. (2007) Emergence of novel color vision in mice engineered to express a human cone photopigment. Science 315: 1723-1725. PMID: 17379811

Chen, J. and Nathans, J. (2007) Estrogen related receptor beta (NR3B2) controls epithelial cell fate and endolymph production by the stria vascularis. Developmental Cell 13: 325-337.PMID: 17765677

Rattner, A., Toulabi, L., Williams, J., Yu, H., Nathans J. (2008) The genomic response of the retinal pigment epithelium to light damage and retinal detachment. Journal of Neuroscience 28: 9880-9889. PMID: 18815272

Liu, C., and Nathans, J. (2008) An essential role for Frizzled5 in mammalian ocular development: loss of Frizzled5 leads to microphthalmia, delayed closure of the optic fissure, persistence of the hyaloid vasculature, and a late retinal degeneration. Development 135: 3567-3576.PMID: 18832390

Rotolo, T., Smallwood, P.M., Williams, J., and Nathans, J. (2008) Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology. Public Library of Science One 3: e4099.PMID: 19116659

Badea, T.C., Cahill, H., Ecker, J., Hattar, S., and Nathans, J. (2009) Distinct roles of transcription factors Brn3a and Brn3b in controlling the development, morphology, and function of retinal ganglion cells. Neuron 61: 852-864.PMID: 19323995

Jacobs, G.H., and Nathans, J. (2009) The evolution of primate color vision. Scientific American 300: 40-47. PMID: 19363921

Ye, X., Wang, Y., Cahill, H., Yu, Y., Badea, T.C., Smallwood, P.M., Peachey, N.S., and Nathans, J. (2009) Norrin, Frizzled4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139: 285-298. PMID: 19837032

Badea, T.C., Hua, L.Z., Smallwood, P.M., Williams, J., Rotolo, T., Ye, X., and Nathans, J. (2009) New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling. Public Library of Science One 16: e7859.PMID: 19323995

Yu, H., Smallwood, P.M., Wang, Y., Vidaltamayo, R., Reed, R., and Nathans, J. (2010) Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development 137:3707-3717.PMID: 20940229

Ye, X., Wang, Y., and Nathans, J. (2010) The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease. Trends in Molecular Medicine 16: 417-425. PMID: 20688566

Wang, Y., Chang, H., and Nathans, J. (2010) When whorls collide: the development of hair patterns in frizzled6 mutant mice. Development 137: 4091-4099. PMID: 21062866

Ye, X., Wang, Y., Rattner, A., and Nathans, J. (2011) Genetic mosaic analysis reveals a major role for frizzled4 and frizzled8 in controlling ureteric growth in the developing kidney. Development 138: 11161-1172. 21343368

Cahill, H., Rattner, A., and Nathans, J. (2011) Preclinical assessment of central nervous system drug action using eye movements in mice. Journal of Clinical Investigation 121: 3528-3541.PMID: 21821912

Badea, T.C., Williams, J., Smallwood, P., Shi, M., Motajo, O., and Nathans, J. (2012) Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis. Journal of Neuroscience 32: 995-1007.PMID: 22262898

Julius, D. and Nathans, J. (2012) Signaling by Sensory Receptors. In Perspectives in Signal Transduction. Series: Cold Spring Harbor Perspectives in Biology. (Cantley, L., Hunter, T., Sever, R., and Thorner, J.W., eds). Cold Spring Harbor, NY: Cold Spring Harbor Press, pp 1-14. PMID: 22110046

Wang, Y., Rattner, A., Zhou, Y., Williams, J., Smallwood, P.M., and Nathans, J. (2012) Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity. Cell 151: 1332-1344. PMID: 23217714

Wu, H., Williams, J., and Nathans, J. (2012) Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling. eLife 1:e00181. PMID: 23256042

Chang, H., and Nathans, J. (2013) Responses of hair follicle-associated structures to loss of planar cell polarity signaling. Proceedings of the National Academy of Sciences USA, E908-E917. PMID: 23431170

Rattner, A., Yu, H. Williams, J., Smallwood, P.M., and Nathans, J. (2013) Endothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proceedings of the National Academy of Sciences USA 110: E3830-E3839. PMID: 24043815

Hua, L., Smallwood, P.M., and Nathans, J. (2013) Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons. eLife 2: e01482. PMID: 24347548

Wu, H., Luo, J, Yu, H., Rattner, A., Mo, A., Smallwood, P.M., Erlanger, B., Wheelan, S.J., and Nathans, J. (2014) Cellular resolution maps of X-chromosome inactivation: implications for neural development, function, and disease. Neuron 81: 103-119. PMID: 24411735

Hua, Z.L., Jeon, S., Caterina, M., and Nathans, J. (2014) Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system. Proceedings of the National Academy of Sciences USA 111: E3005-3014. PMID: 24799694

Wu, H., Williams, J., and Nathans, J. (2014) Complete morphologies of basal forebrain cholinergic neurons in the mouse. eLife 3:e02444. PMID: 24894464

Zhou, Y., Wang, Y., Tischfield, M., Williams, J., Smallwood, P.M., Rattner, A., Taketo, M.M., and Nathans, J. (2014) Canonical Wnt signaling components in vascular development and barrier formation. Journal of Clinical Investigation 124: 3825-3846. PMID: 25083995

Mo, A., Mukamel, E.A., Davis, F.P., Luo, C., Henry, G.L., Picard, S., Urich, M.A., Nery, J.R., Sejnowski, T.J., Lister, R., Eddy, S.R., Ecker, J.R., and Nathans, J. (2015) Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain. Neuron 86:1369-1384. PMID: 26087164,

Chang, H., Cahill, H., Smallwood, P.M., Wang, Y., and Nathans, J. (2015) Identification of Astrotactin2 as a genetic modifier that regulates the global orientation of mammalian hair follicles. PLOS Genetics 11: e1005532. PMID: 26418459

Chang, H., Smallwood, P.M., Williams, J., and Nathans, J. (2016) The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation. Developmental Biology 409: 181-193. PMID: 26517967

Mo, A., Luo, C., Davis, F.P., Mukamel, E.A., Henry, G.L., Nery, J.R., Urich, M.A., Picard, S., Lister, R., Eddy, S.R., Beer, M.A., Ecker, J.R., and Nathans, J. (2016) Epigenomic landscapes of retinal rods and cones. Elife 5: e11613. PMID: 26949250

Wang, Y., Williams, J., Rattner, A., Wu, S., Bassuk, A.G., Goffinet, A.M., and Nathans, J. (2016) Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling. Developmental Biology 419: 298-310. PMID: 27612405

Wang, Y., Chang, H., Rattner, A., and Nathans, J. (2016) Frizzled receptors in development and disease. Current Topics in Developmental Biology 117: 113-139. PMID: 26969975

Nathans, J. and Sterling, P. (2016) How scientists can reduce their carbon footprint. Elife 5: e15928. PMID: 27029962

Chang, H., Smallwood, P.M., Williams, J., and Nathans, J. (2017) Intramembrane proteolysis of Astrotactins. Journal of Biological Chemistry 292: 3506-3516. PMID: 28100779

Cho C., Smallwood P.M., and Nathans J. (2017) Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron 95: 1056-1073. PMID: 28858622

Sabbagh, M.F., Heng, J.S., Luo, C., Castanon, R.G., Nery, J.R., Rattner, A., Goff, L.A., Ecker, J.R., Nathans, J. (2018) Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells. eLife 7: e36187. PMID: 28858622

Peng, X., Emiliani, F., Smallwood, P.M., Rattner, A., Lei, H., Sabbagh, M.F., and Nathans, J. (2018) Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions. eLife 7: e40982. PMID: 30345971

Wang, Y., Cho, C., Williams, J., Smallwood, P.M., Zhang, C., Junge, H.J., and Nathans, J. (2018) Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proceedings of the National Academy of Sciences USA 15: E11827-E11836. PMID: 30478038

Wang ,Y., Sabbagh, M.F., Gu, X., Rattner, A., Williams, J., and Nathans, J. (2019) Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures. eLife 8: e43257. PMID: 30932813

Heng, J.S., Rattner, A., Stein-O’Brien, G.L., Winer, B.L., Jones, B.W., Vernon, H.J., Goff, L.A., and Nathans, J. (2019) Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution. Proceedings of the National Academy of Sciences USA 116:9103-9114. PMID: 30988181

Cho, C., Wang, Y., Smallwood, P.M., Williams, J., and Nathans, J. (2019) Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. eLife, e45542 PMID: 31066677